<aside> 👋🏽 You’ll find all my writings, frameworks, and thoughts on crypto, AI and investing more broadly. I hope this is helpful to whoever comes across this. Enjoy! 🙏🏾

</aside>

About Me

My name is Karthik Senthil (@karsenthil). I’m a builder, 2X founder, former venture partner at Lattice (early-stage crypto VC), active angel investor (25+ investments), advisor, writer, and observer. Most recently, I was the general manager (GM) of ZKsync Era leading product/strategy/ecosystem/growth. Previously, I led engineering + product teams at Amazon, Circle, Goldman Sachs, and startups. I live in NYC with my wife and two daughters (being a girl-dad is the best!).

My Writing

Secular Investment Themes (Mar 2026)

<aside> 📝 My investment themes and biggest opportunities across macro, AI and crypto

</aside>

The Crowdsourced Training Stack (Nov 2025)

<aside> 📝 I co-authored a long-form piece on the crowdsourced training stack and why I believe it represents a massive PMF opportunity for blockchains

</aside>

Open Letter to AI Builders on Why Crypto (Mar 2025)

<aside> 📝 I published an open letter to AI builders on why they should build on crypto

</aside>

AI X Crypto Thesis (Jan 2025)

<aside> 📝 I published my AI X crypto thesis and why we’re at a step function moment in crypto

</aside>

DeData

https://x.com/karsenthil/status/1858875324081336743

The Crypto PR-FAQ

<aside> 📝 I published the Crypto PR-FAQ that uses my learnings from my time at Amazon to take a user-centric approach for the industry to help us find PMF (Sep 2023)

</aside>

https://twitter.com/karsenthil/status/1704128757441900708

Middleware Thesis

<aside> 🗒️ I published my Middleware thesis on the future of crypto architecture (April 2023)

</aside>